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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
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1985 2
1986 1
1987 3
1989 7
1990 4
1991 2
1992 7
1995 1
1996 3
1997 4
1998 1
1999 2
2000 1
2001 2
2002 1
2003 1
2004 5
2005 3
2006 1
2007 4
2008 5
2009 3
2010 1
2011 4
2012 3
2013 7
2014 6
2015 3
2016 4
2017 4
2018 1
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2020 7
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2024 3

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Page 1
Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.
Park KH, Lee SC, Yuk JE, Kim SR, Lee JH, Park JW. Park KH, et al. Allergy Asthma Immunol Res. 2019 Mar;11(2):231-240. doi: 10.4168/aair.2019.11.2.231. Allergy Asthma Immunol Res. 2019. PMID: 30661315 Free PMC article.
As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. ...There were 35 patients with anaphylaxis, comprising 16.9% of the eperisone-related ADRs. In the single center study, there were 11 patients with eperisone-induced …
As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. ...There were 35 patients with anaphyla …
Pharmacokinetics of eperisone following oral administration in healthy Korean volunteers.
Baek IH, Back HM, Chae JW, Ha ES, Park H, Choi DH, Staatz CE, Kim MS. Baek IH, et al. Biopharm Drug Dispos. 2021 Mar;42(2-3):94-102. doi: 10.1002/bdd.2264. Epub 2021 Mar 3. Biopharm Drug Dispos. 2021. PMID: 33527395 Clinical Trial.
Eperisone is an oral muscle relaxant used to treat musculoskeletal diseases, which exhibits high pharmacokinetic (PK) variability in bioequivalence studies. ...Aspartate aminotransferase level and smoking status were identified as potential covariates that may influence th …
Eperisone is an oral muscle relaxant used to treat musculoskeletal diseases, which exhibits high pharmacokinetic (PK) variability in …
Clinical characteristics of eperisone-induced immediate-type hypersensitivity.
Shin B, Yoon SY, Lee JH, Won HK, An J, Kang Y, Song WJ, Kim TB, Cho YS, Moon HB, Kwon HS. Shin B, et al. Asian Pac J Allergy Immunol. 2020 Dec;38(4):279-285. doi: 10.12932/AP-211018-0420. Asian Pac J Allergy Immunol. 2020. PMID: 30903996 Free article.
BACKGROUND: Eperisone is a commonly prescribed oral muscle relaxant, but few studies have been conducted of eperisone-induced hypersensitivity reactions. OBJECTIVE: The purpose of this study was to investigate the clinical manifestations of eperisone-induced …
BACKGROUND: Eperisone is a commonly prescribed oral muscle relaxant, but few studies have been conducted of eperisone-induced …
Clinical efficacy and safety of eperisone for low back pain: A systematic literature review.
Bavage S, Durg S, Ali Kareem S, Dhadde SB. Bavage S, et al. Pharmacol Rep. 2016 Oct;68(5):903-12. doi: 10.1016/j.pharep.2016.05.003. Epub 2016 Jun 29. Pharmacol Rep. 2016. PMID: 27371896 Review.
Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP). ...Eperisone also improved paraspinal blood flow and was found to have efficacy similar to tizanidine in chronic LBP patients. ...
Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP). ...Eperison …
Therapeutic effects of eperisone on pulmonary fibrosis via preferential suppression of fibroblast activity.
Tanaka KI, Shimoda M, Sugizaki T, Ikeda M, Takafuji A, Kawahara M, Yamakawa N, Mizushima T. Tanaka KI, et al. Cell Death Discov. 2022 Feb 8;8(1):52. doi: 10.1038/s41420-022-00851-7. Cell Death Discov. 2022. PMID: 35136056 Free PMC article.
Eperisone also significantly inhibited transforming growth factor-beta1-dependent transdifferentiation of LL29 cells into myofibroblasts. ...Considering these results, we propose that eperisone may be safer and more therapeutically beneficial for IPF patients than c …
Eperisone also significantly inhibited transforming growth factor-beta1-dependent transdifferentiation of LL29 cells into myofibrobla …
Eperisone hydrochloride-induced maculopapular rash.
Balaraddiyavar N, Bhushan A, Kotinatot BC, Huggi G. Balaraddiyavar N, et al. Indian J Pharmacol. 2016 Sep-Oct;48(5):604-605. doi: 10.4103/0253-7613.190765. Indian J Pharmacol. 2016. PMID: 27721553 Free PMC article.
Here, we report a case of a 30-year-old male who was prescribed eperisone hydrochloride for body pain and loose stools after which he developed severe maculopapular rash. Eperisone hydrochloride is an analgesic and antispastic drug used for spastic diseases such as …
Here, we report a case of a 30-year-old male who was prescribed eperisone hydrochloride for body pain and loose stools after which he …
Serum concentration of eperisone hydrochloride correlates with QT interval.
Yamagiwa T, Morita S, Amino M, Miura N, Saito T, Inokuchi S. Yamagiwa T, et al. Am J Emerg Med. 2014 Jan;32(1):75-7. doi: 10.1016/j.ajem.2013.09.006. Epub 2013 Oct 15. Am J Emerg Med. 2014. PMID: 24135462
Although a case of eperisone-induced severe QT prolongation had been reported, the relationship between serum eperisone concentration and QT interval remains obscure. ...The correlation coefficient was 0.833 between serum eperisone concentration and QTc inter …
Although a case of eperisone-induced severe QT prolongation had been reported, the relationship between serum eperisone concen …
Enantioselective carbonyl reduction of eperisone in human liver microsomes.
Yoo HH, Kim NS, Kim MJ, Shin D, Shin JG, Kim DH. Yoo HH, et al. Xenobiotica. 2011 Sep;41(9):758-63. doi: 10.3109/00498254.2011.576277. Epub 2011 May 31. Xenobiotica. 2011. PMID: 21623702
As eperisone is a racemic compound with one chiral centre, the carbonyl reduced metabolite of eperisone (M5) may have four possible diastereoisomeric structures. Chiral separation of incubation mixtures of racemic eperisone with human liver microsome revealed …
As eperisone is a racemic compound with one chiral centre, the carbonyl reduced metabolite of eperisone (M5) may have four pos …
Efficacy and tolerability of eperisone and baclofen in spastic palsy: a double-blind randomized trial.
Bresolin N, Zucca C, Pecori A. Bresolin N, et al. Adv Ther. 2009 May;26(5):563-73. doi: 10.1007/s12325-009-0031-8. Epub 2009 May 20. Adv Ther. 2009. PMID: 19458926 Clinical Trial.
Both treatments reduced the 10-meter walking time (eperisone: -20.2%, P<0.01; baclofen: -24.0%, P<0.01); this effect was evident at week 2 with eperisone only. Both drugs improved reflexes. Eperisone and baclofen decreased the Hmax/Mmax amplitude ratio …
Both treatments reduced the 10-meter walking time (eperisone: -20.2%, P<0.01; baclofen: -24.0%, P<0.01); this effect was eviden …
Eperisone Hydrochloride, a Muscle Relaxant, Is a Potent P2X7 Receptor Antagonist.
Okada M, Nose T. Okada M, et al. Chem Pharm Bull (Tokyo). 2024;72(3):345-348. doi: 10.1248/cpb.c24-00032. Chem Pharm Bull (Tokyo). 2024. PMID: 38556262 Free article.
Eperisone Hydrochloride was launched in Japan in 1983 and has been used to improve muscle tone and treat spastic paralysis (Originator: Eisai Co., Ltd.). ...Also, P2X receptor subtype selectivity was high. This finding demonstrates the (Eperisone-P2X7-pain linkage), …
Eperisone Hydrochloride was launched in Japan in 1983 and has been used to improve muscle tone and treat spastic paralysis (Originato …
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